SML1726

MSAB

≥95% (HPLC)

• Synonyme(s) : 3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester, Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate, WI-21
• Formule empirique (notation de Hill) : C₁₅H₁₅NO₄S
• Numéro CAS: 173436-66-3
• Poids moléculaire : 305.35
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826041
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Couleur: off-white to purple
• Solubilité: DMSO: 25 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1
• Clé InChI: CVKBYFCJQSPBOI-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

A cellular β-catenin degradation inducer with anti-proliferation efficacy against Wnt-dependent cancer growth both in vitro and in vivo.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable