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SML0951

Sigma-Aldrich

Salubrinal

≥98% (HPLC)

Synonyme(s) :

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl] 2-propenamide

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About This Item

Formule empirique (notation de Hill):
C21H17Cl3N4OS
Numéro CAS:
405060-95-9
Poids moléculaire :
479.81
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

, white to light yellow to light gray

Solubilité

DMSO: 20 mg/mL, clear

Température de stockage

−20°C

InChI

1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+

Clé InChI

LCOIAYJMPKXARU-VAWYXSNFSA-N

Application

Salubrinal has been used to study the effect of stress-protective genes and pathways on organism development and lifespan. It has also been used to study the therapeutic potential of salubrinal in methamphetamine induced blood–brain barrier disruption.

Actions biochimiques/physiologiques

Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.
Salubrinal maintains protein phosphorylation in order to offer protection against from the adverse effects of endoplasmic reticulum stress. Salubrinal prevents collagenase-mediated articular cartilage damage promoting downregulation of matrix metalloproteinase 13.

Caractéristiques et avantages

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315 - H319 - H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Rescue of a developmental arrest caused by a C. elegans heat-shock transcription-factor mutation by loss of ribosomal S6-kinase activity.
Chisnell P J D, et al.
bioRxiv, 310086-310086 (2018)
K Hamamura et al.
Osteoarthritis and cartilage, 21(5), 764-772 (2013-03-12)
Stress to the endoplasmic reticulum (ER) and inflammatory cytokines induce expression and activity of matrix metalloproteinase 13 (MMP13). Since a synthetic agent, salubrinal, is known to alleviate ER stress and attenuate nuclear factor kappa B (NFκB) signaling, we addressed a
Daphne E Lodes et al.
Journal of neurochemistry, 160(6), 613-624 (2021-12-23)
The neural precursor cell expressed developmentally down-regulated protein 4-like (Nedd4-2) is an E3 ubiquitin ligase critical for neurodevelopment and homeostasis of neural circuit excitability. While dysregulation of Nedd4-2 has been linked to elevated seizure susceptibility through impaired ubiquitination of multiple
Muhammad M Hossain et al.
Toxicological sciences : an official journal of the Society of Toxicology, 167(1), 249-257 (2018-09-25)
Endoplasmic reticulum (ER) stress is a significant contributor to neurodegeneration and cognitive dysfunction. Recently, we reported that repeated exposure to the pyrethroid insecticide deltamethrin caused ER stress in the hippocampus of adult mice, which was accompanied by deficits in learning
Protection of Bcl-2 by salubrinal.
Kessel D.
Biochemical and Biophysical Research Communications, 346(4), 1320-1323 (2006)
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