SML0222

TVP1022

≥98% (HPLC)

• Synonyme(s) : (1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine, (S)-Rasagiline, S-(-)-N-Propargyl-1-aminoindan
• Formule empirique (notation de Hill): C₁₂H₁₃N
• Numéro CAS: 185517-74-2
• Poids moléculaire : 171.24
• Numéro MDL: MFCD09029306
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825241
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Solubilité: DMSO: ≥15 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: C#CCN[C@H]1CCc2ccccc12
• InChI: 1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
• Clé InChI: RUOKEQAAGRXIBM-LBPRGKRZSA-N

Description

Actions biochimiques/physiologiques

TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H400
• Conseils de prudence: P273 - P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable