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SML0115

Sigma-Aldrich

MDL 11939

≥98% (HPLC)

Synonyme(s) :

α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol, Glemanserin, MDL11939

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About This Item

Formule empirique (notation de Hill):
C20H25NO
Numéro CAS:
107703-78-6
Poids moléculaire :
295.42
Numéro MDL:
MFCD00864701
Code UNSPSC :
12352200
ID de substance PubChem :
329825167
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to tan

Solubilité

DMSO: ≥8 mg/mL

Auteur

Sanofi Aventis

Température de stockage

2-8°C

Chaîne SMILES 

OC(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3

InChI

1S/C21H27NO/c23-21(19-11-5-2-6-12-19)20-13-16-22(17-14-20)15-7-10-18-8-3-1-4-9-18/h1-6,8-9,11-12,20-21,23H,7,10,13-17H2

Clé InChI

CTDVLAJTGZQELM-UHFFFAOYSA-N

Actions biochimiques/physiologiques

MDL 11,939 is a potent, selective and orally active 5-HT2 receptor antagonist (ASTAR). Ki values values are in the low nanomolar range for 5-HT2A with over 100-fold selectivity over 5-HT2C receptors and low or no affinity for non-5-HT2 receptors or transporters.

Caractéristiques et avantages

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Environment
GHS09

Mention d'avertissement

Warning

Mentions de danger

H400

Conseils de prudence

P273 - P391 - P501

Classification des risques

Aquatic Acute 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A G Romano et al.
Psychopharmacology, 184(2), 173-181 (2005-12-22)
Associative learning during Pavlovian eyeblink conditioning has been shown to be regulated by 5-HT2A receptors. The existence of inverse agonists that retard learning through an action at the 5-HT2A receptor suggests the existence of constitutive activity at that receptor and
Kuldip D Dave et al.
Psychopharmacology, 176(3-4), 287-295 (2004-04-27)
Motor movements (head bobs) in the rabbit have been shown to be elicited by LSD-like hallucinogenic drugs through actions at central serotonin 5-HT(2A) receptors, though their central locus remains unknown. Serotonergic innervation of the hippocampus has been suggested to play
Meredith A Fox et al.
Neuropharmacology, 53(5), 643-656 (2007-09-04)
Administration of serotonin-enhancing drugs induces a distinctive behavioral syndrome in rodents. We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug. In the current studies
S E Welsh et al.
Psychopharmacology, 137(2), 157-163 (1998-06-18)
The 5-HT(2A/2C) receptor antagonist, ritanserin, was reported to retard the acquisition of conditioned responses (CRs) during classical conditioning of the rabbit's nictitating membrane (NM) response. The present study compared the effects of ritanserin on acquisition of CRs to a tone
C R Ashby et al.
Synapse (New York, N.Y.), 10(1), 7-15 (1992-01-11)
In the present study, we investigated the effects of various serotonin (5-HT) antagonists on 5-HT's action on medial prefrontal cortical cells (mPFc) using the techniques of single cell recording and microiontophoresis. The microiontophoretic application of 5-HT (10-80 nA) produced a
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