Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

SML0003

Sigma-Aldrich

CID755673

≥98% (HPLC), powder

Synonyme(s) :

2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one, 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme


About This Item

Formule empirique (notation de Hill):
C12H11NO3
Numéro CAS:
Poids moléculaire :
217.22
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to tan

Solubilité

DMSO: ≥15 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Oc1ccc2oc3C(=O)NCCCc3c2c1

InChI

1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)

Clé InChI

AACFPJSJOWQNBN-UHFFFAOYSA-N

Application

CID755673 was used to study the role of PKD in dendrite retraction in mouse Purkinje cells.

Actions biochimiques/physiologiques

CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1 (PKCμ), PKD2, and PKD3 (PKCν). CID755673 is not competitive with ATP.
CID755673 was not suitable to inhibit PKD in Swiss 3T3 cells as it utilizes PKD-dependent pathway to enhance the mitogenic signaling triggered by EGF, phorbol esters and bombesin. It should, therefore, be used with caution.

Caractéristiques et avantages

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ali Pedram et al.
Molecular biology of the cell, 24(24), 3805-3818 (2013-10-25)
The development and progression of cardiac hypertrophy often leads to heart failure and death, and important modulators of hypertrophy include the histone deacetylase proteins (HDACs). Estrogen inhibits cardiac hypertrophy and progression in animal models and humans. We therefore investigated the
Kazuto Fujishima et al.
Development (Cambridge, England), 139(18), 3442-3455 (2012-08-23)
Neurons develop dendritic arbors in cell type-specific patterns. Using growing Purkinje cells in culture as a model, we performed a long-term time-lapse observation of dendrite branch dynamics to understand the rules that govern the characteristic space-filling dendrites. We found that
Nayden G Naydenov et al.
Tissue barriers, 1(4), e25231-e25231 (2014-03-26)
The ductal epithelium plays a key role in physiological secretion of pancreatic enzymes into the digestive system. Loss of barrier properties of the pancreatic duct may contribute to the development of pancreatitis and metastatic dissemination of pancreatic tumors. Proinflammatory cytokines
Christine Kienzle et al.
Molecular biology of the cell, 24(3), 222-233 (2012-12-18)
Before entering mitosis, the stacks of the Golgi cisternae are separated from each other, and inhibiting this process delays entry of mammalian cells into mitosis. Protein kinase D (PKD) is known to be involved in Golgi-to-cell surface transport by controlling
Eugenia Torres-Marquez et al.
Biochemical and biophysical research communications, 391(1), 63-68 (2009-11-10)
Recently, CID755673 was reported to act as a highly selective inhibitor of protein kinase D (PKD). In the course of experiments using CID755673, we noticed that it exerted unexpected stimulatory effects on [(3)H]thymidine incorporation and cell cycle progression in Swiss

Articles

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique