SMB00912
Pseudouridine
≥98% (HPLC)
Synonyme(s) :
Pseudouridine, β-Pseudouridine, ψ-Uridine, 5-(β-D-Ribofuranosyl)uracil
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About This Item
Formule empirique (notation de Hill):
C9H12N2O6
Numéro CAS:
Poids moléculaire :
244.20
Code UNSPSC :
41106305
Nomenclature NACRES :
NA.79
Produits recommandés
Source biologique
synthetic (chemical)
Niveau de qualité
Essai
≥98% (HPLC)
Forme
powder
Poids mol.
244.2
Couleur
white to off-white
Pf
222 °C ((432 °F ))
Solubilité
water: soluble
Température de stockage
2-8°C
InChI
1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
Clé InChI
PTJWIQPHWPFNBW-GBNDHIKLSA-N
Description générale
Pseudouridine (Ψ) stands as an isomer of the nucleoside uridine, featuring a carbon-carbon bond instead of the typical nitrogen-carbon glycosidic bond connecting uracil. It represents the most prevalent among the myriad modified nucleosides within RNA, with a presence spanning various species and RNA classes. The enzymatic action of Ψ synthases induces post-transcriptional isomerization of specific uridine residues, a process known as pseudouridylation. This modification, particularly in rRNA and tRNA, plays a vital role in fine-tuning and stabilizing regional structures, contributing to mRNA decoding, ribosome assembly, processing, and translation functions. Moreover, β-pseudouridine, identified in tRNAs across bacteria, archaea, and eukaryotes, has demonstrated potential in reducing radiation-induced chromosome aberrations in human lymphocytes. Its utility as a cancer and proliferation biomarker positions it as a valuable asset in metabolomics and biochemical research.
Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a β-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite. Pseudouridine is found in all species and in all classes of RNA except mRNA. It is formed by enzymes called pseudouridine synthases, which post-transcriptionally isomerize specific uridine residues in RNA.
Application
Pseudouridine is a versatile compound and a biomarker that finds application in metabolomics and biochemical research.
Caractéristiques et avantages
- High-purity compound suitable for a wide variety of research applications
Autres remarques
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Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
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Biomaterials, 266, 120431-120431 (2020-10-26)
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The EMBO journal, 39(20), e104708-e104708 (2020-09-15)
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Matthias Heiss et al.
Nature communications, 12(1), 389-389 (2021-01-17)
Recently, studies about RNA modification dynamics in human RNAs are among the most controversially discussed. As a main reason, we identified the unavailability of a technique which allows the investigation of the temporal processing of RNA transcripts. Here, we present
Tingting Jiang et al.
Nature communications, 11(1), 1979-1979 (2020-04-26)
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Tatsuro Hagi et al.
Applied microbiology and biotechnology, 104(24), 10641-10653 (2020-11-08)
Akkermansia muciniphila is a prominent member of the gut microbiota and the organism gets exposed to bile acids within this niche. Several gut bacteria have bile response genes to metabolize bile acids or an ability to change their membrane structure
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