SAB4702025

Monoclonal Anti-EGFR PE produced in mouse

• Synonyme(s) : EGF-R, ERBB1, Her1, NISBD2, PIG61
• Code UNSPSC : 12352203

Propriétés

• Conjugué: phycoerythrin (R-PE) conjugate
• Niveau de qualité: 100
• Type de produit anticorps: primary antibodies
• Clone: EGFR1, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: horse, ( Human)
• Technique(s): flow cytometry: suitable
• Isotype: IgG2bκ
• Numéro d'accès UniProt: P00533
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... EGFR(1956)

Description

Description générale

The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.

Spécificité

The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.

Immunogène

Human epidermoid carcinoma line A431

Forme physique

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Notes préparatoires

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Stockage et stabilité

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Autres remarques

The antibody solution should be gently mixed before use.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable