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Key Documents

SAB4504388

Sigma-Aldrich

Anti-phospho-eIF2 α (pSer51) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-EIF-2, Anti-EIF-2A, Anti-EIF-2alpha, Anti-EIF2, Anti-EIF2A

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 36 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer51)

Informations sur le gène

human ... EIF2S1(1965)

Description générale

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) is a heterotrimeric protein and a regulatory subunit of eIF2 . eIF2 has three general subunits- α, βand γ . eIF2α is located on human chromosome 14q23 .

Immunogène

The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51.

Immunogen Range: 21-70

Application

Anti-phospho-eIF2 α(pSer51) antibody has been used in western blotting and immunohistochemistry.

Actions biochimiques/physiologiques

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) acts as a modulator in apoptosis signaling pathway . During endoplasmic reticulum stress, eIF2α plays a major role in signaling pathways in the development of tumor .

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Translational regulator eIF2? in tumor
Zheng Q, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35(7), 6255-6264 (2014)
Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats
Ko AR, et al.
Neuroscience, 307, 199-214 (2015)
Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response
Larroquette F, et al.
Human Molecular Genetics, 24(22), 6515-6529 (2015)
Isabella R Straub et al.
Human molecular genetics, 30(8), 687-705 (2021-03-23)
Mutations in CHCHD10, coding for a mitochondrial intermembrane space protein, are a rare cause of autosomal dominant amyotrophic lateral sclerosis. Mutation-specific toxic gain of function or haploinsufficiency models have been proposed to explain pathogenicity. To decipher the metabolic dysfunction associated
The Role of the PERK/eIF2?/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
Rozpedek W, et al.
Current Molecular Medicine, 16(6), 533-544 (2016)

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