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Key Documents

SAB4503834

Sigma-Aldrich

Anti-phospho-SGK (pSer422) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 48 kDa

Espèces réactives

rat, human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

O00141

Numéro d'accès UniProt

O00141

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer422)

Informations sur le gène

human ... SGK1(6446)

Description générale

The serum- and glucocorticoid-regulated kinase (Sgk1) is a member of the AGC kinase family. It is located on human chromosome 6q23.

Immunogène

The antiserum was produced against synthesized peptide derived from human SGK around the phosphorylation site of Ser422.

Immunogen Range: 381-430

Actions biochimiques/physiologiques

The serum- and glucocorticoid-regulated kinase (Sgk1) controls ENaC (expressed renal epithelial Na+ channel) by mineralocorticoids. SGK1 controls p27 phosphorylation upon the activation by mTOR-Raptor.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Saniya Ossikbayeva et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Anticancer activities of plant polyphenols have been demonstrated in various models of neoplasia. However, evidence obtained in numerous in vitro studies indicates that proliferation arrest and/or killing of cancer cells require quite high micromolar concentrations of polyphenols that are difficult
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
Ellison DW, et al.
Journal of Clinical Oncology, 29(11), 1400-1407 (2011)
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
Hong F, et al.
Molecular Cell, 30(6), 701-711 (2008)
Impaired renal Na(+) retention in the sgk1-knockout mouse
Wulff P, et al.
The Journal of Clinical Investigation, 110(9), 1263-1268 (2002)
Bidisha Saha et al.
Journal of cell science, 135(23) (2022-11-15)
Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has well-characterized roles in mediating hormone and growth factor effects on a wide array
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