SAB4502988
Anti-TNF Receptor I antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
CD120a, TBPI, TNF-RI, p55, p60
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 50 kDa
Espèces réactives
human, mouse, rat
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TNFRSF1A(7132)
Description générale
Tumor necrosis factor receptor 1 (TNFR1) belongs to the TNFR superfamily and is ubiquitously expressed. It comprises an extracellular domain with a cysteine-rich motif, a transmembrane segment, and an intracellular domain with a “death domain” motif. The TNFR1 gene is mapped to human chromosome 12p13.31.
Immunogène
The antiserum was produced against synthesized peptide derived from human TNF Receptor I.
Immunogen Range: 381-430
Immunogen Range: 381-430
Application
Anti-TNF Receptor I antibody produced in rabbit has been used in immunostaining at a dilution of 1:200.
Actions biochimiques/physiologiques
Tumor necrosis factor receptor 1 (TNFR1) is crucial for TNF for eliciting proinflammatory functions. Through its dead domain motif, TNFR1 interacts with the TNF receptor-associated death domain protein (TRADD). TNFR1 regulates cytotoxic signaling pathways. Blockage of TNFR1 in mouse model harboring respiratory syncytial virus (RSV) infection results in enhanced bronchoconstriction.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.
Yang, et al.
Frontiers in Immunology, 9, 784-784 (2019)
The death domain of tumor necrosis factor receptor 1 is necessary but not sufficient for Golgi retention of the receptor and mediates receptor desensitization.
Gaeta, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 80, 1185-1194 (2019)
Dorothea R Morris et al.
Viruses, 12(10) (2020-10-22)
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infants and young children. Although some clinical studies have speculated that tumor necrosis factor (TNF)-α is a major contributor of RSV-mediated airway disease, experimental evidence remains unclear or conflicting.
Antonio-Jesús Jiménez et al.
Neuropathology and applied neurobiology, 40(7), 911-932 (2014-04-09)
Here, we tested the hypothesis that glial responses via the production of cytokines such as transforming growth factor-beta 1 (TGFβ1) and tumour necrosis factor alpha (TNFα), which play important roles in neurodegenerative diseases, are correlated with the severity of congenital
Agnieszka Segiet et al.
Cytokine, 113, 185-194 (2018-12-13)
A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays
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