SAB4502262
Anti-PPAR-γ antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
NR1C3, PPAR-γ-1, Peroxisome proliferator activated receptor γ
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 57 kDa
Espèces réactives
mouse, rat, human
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PPARG(5468)
Catégories apparentées
Description générale
Peroxisome proliferator-activated receptor γ (PPARγ) is one of the subtypes of PPAR, and belongs to the nuclear hormone receptor superfamily. PPARγ is further sub classified into four isoforms and they have tissue specific expression. PPARγ is encoded by the gene mapped to human chromosome 3p25. PPARγ contains N- terminal AF (activation function)-1 transactivation domain, followed by a DNA-binding domain and a dimerization and ligand-binding domain.
Immunogène
The antiserum was produced against synthesized peptide derived from human PPAR-gamma.
Immunogen Range: 78-127
Immunogen Range: 78-127
Actions biochimiques/physiologiques
Peroxisome proliferator-activated receptor γ (PPARγ) induces the expression of genes coding for proteins implicated in glucose and lipid metabolism. Natural PPAR-γ agonists found in foods functions as an anti-inflammatory molecule, thus, PPARγ is not only a target of the pharmaceutical industry, but also a novel target of the food industry. PPAR-γ regulates energy storage, adipocyte differentiation, and cellular inflammatory and ischemic responses. PPARγ is also involved in the production of prostanoids that regulate vascular function. PPARγ agonists, thiazolidinediones including rosiglitazone and pioglitazone, enhance insulin sensitivity by inhibiting the tumor necrosis factor α (TNF-α) activity in adipocytes. These PPAR-γ agonists are used in the treatment of type 2 diabetes. PPARγ functions as a potential therapeutic target in pulmonary hypertension.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vous ne trouvez pas le bon produit ?
Essayez notre Outil de sélection de produits.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Faites votre choix parmi les versions les plus récentes :
Certificats d'analyse (COA)
Lot/Batch Number
Vous ne trouvez pas la bonne version ?
Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases.
Tyagi S
Journal of Advanced Pharmaceutical Technology & Research, 2(4), 236-240 (2011)
PPARgamma as a potential therapeutic target in pulmonary hypertension.
Sutliff RL
Therapeutic Advances in Respiratory Disease, 4(3), 143-160 (2010)
Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock.
Abdelrahman M
Cardiovascular Research, 65(4), 772-781 (2005)
Mariami Jasaszwili et al.
Molecular and cellular endocrinology, 496, 110532-110532 (2019-08-11)
Adropin is a protein encoded by Energy Homeostasis Associated (Enho) gene which is expressed mainly in the liver and brain. There is evidence that biological effects of adropin are mediated via GPR19 activation. Animal studies showed that adropin modulates adiposity
Anna Salazar-Degracia et al.
Biochimie, 149, 79-91 (2018-04-15)
Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Beta-adrenoceptors attenuate muscle wasting. We hypothesized that specific muscle atrophy signaling pathways and altered metabolism may be attenuated in cancer cachectic animals receiving treatment with
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique