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Key Documents

SAB4502211

Sigma-Aldrich

Anti-PLK1 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

PLK-1, Polo-like kinase 1, STPK13, Serine/threonine-protein kinase 13

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About This Item

Numéro MDL:
MFCD01634025
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 68 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

Numéro d'accès NCBI

P53350

Numéro d'accès UniProt

P53350

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PLK1(5347)

Description générale

Anti-PLK1 Antibody detects endogenous levels of total PLK1 protein.
PLK1 (polo like kinase 1) gene is mapped to human chromosome 16p12.2. It codes for the protein serine/threonine kinase.

Immunogène

The antiserum was produced against synthesized peptide derived from human PLK1.

Immunogen Range: 176-225

Actions biochimiques/physiologiques

PLK1 (polo like kinase 1) is predominantly involved in mitosis. It mediates the phosphorylation of cyclin B1/CDK1 (cyclin dependent kinase 1) complex, and activation of the anaphase promoting complex. PLK1 has anti-apoptotic function. Upregulation of gene is observed in different types of cancer, such as colorectal cancer and is regarded as an oncogene. PLK1 is involved in checkpoint recovery and adaptation following DNA damage.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein ? to mediate colon carcinoma cell differentiation and apoptosis.
Dasgupta N
Biochimica et Biophysica Acta, 1861(7), 1777-1787 (2017)
Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
Rouquier S
Disease Markers, 2014:798170, 1-6 (2014)
PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas.
Koncar RF
Oncotarget, 8(9), 15827-15837 (2017)
Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma.
Amani V
BMC Cancer, 16:647, 1-9 (2016)
Isidre Ferrer et al.
The Journal of pathology, 233(3), 247-257 (2014-03-08)
Most patients with tuberous sclerosis complex (TSC) develop cortical tubers that cause severe neurological disabilities. It has been suggested that defects in neuronal differentiation and/or migration underlie the appearance of tubers. However, the precise molecular alterations remain largely unknown. Here

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