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Key Documents

SAB4501317

Sigma-Aldrich

Anti-MYLIP antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Inducible degrader of the low-density lipoprotein receptor, E3 ubiquitin-protein ligase MYLIP, MIR, Myosin regulatory light chain-interacting protein

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 49 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q8WY64

Numéro d'accès UniProt

Q8WY64

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MYLIP(29116)

Description générale

The MYLIP (myosin regulatory light chain interacting protein) gene is mapped to human chromosome 6p22.3. The encoded protein is an E3 ubiquitin ligase, expressed in all tissues including hippocampus and cerebellum. Anti-MYLIP antibody detects endogenous levels of total MYLIP protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human MYLIP.

Immunogen Range: 161-210

Application

Anti-MYLIP antibody produced in rabbit has been used in western blot analysis.

Actions biochimiques/physiologiques

MYLIP (myosin regulatory light chain interacting protein) controls the LDLR (low density lipoprotein receptor) activity and stability, which might change due to fluctuation in the intracellular cholesterol levels. Mylip is associated with brain development. It induces platelet-derived growth factor (PDGF) signaling in fibroblasts. Mylip is also called as inducible degrader of the LDL-R (Idol), as it leads to receptor degradation, especially in macrophages and liver. It might serve as a target for drug development in disease.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Qi Yu et al.
Molecular medicine reports, 18(3), 2780-2788 (2018-07-18)
Low‑density lipoprotein receptors (LDLRs) may serve a role in the diabetogenic effect of statins; however, the effects of statins on LDLR expression and its regulation in the pancreas and islets have yet to be determined. To exclude the long‑term effects
RP1-13d10. 2 is a novel modulator of statin-induced changes in cholesterol
Mitchel K, et al.
Circulation: Genomic and Precision Medicine, 9(3), 223-230 (2016)
Shuman Liu et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(3), 538-543 (2013-10-30)
Nephrotic syndrome (NS) leads to elevation of serum total and LDL cholesterol. This is largely due to impaired LDL clearance, which is caused by hepatic LDL receptor (LDLR) deficiency despite normal LDLR mRNA expression, pointing to a post-transcriptional process. The
Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome
Liu S and Vaziri ND
Nephrology, Dialysis, and Transplantation, 29(3), 538-543 (2013)
The link between phenotype and fatty acid metabolism in advanced chronic kidney disease
Chen DQ, et al.
Lipids in Health and Disease, 32(7), 1154-1166 (2017)
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