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Key Documents

SAB4301078

Sigma-Aldrich

Anti-TDP2 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

AD022, EAP2, EAPII, TTRAP, hTDP2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

41 kDa

Espèces réactives

human, mouse

Concentration

2.6 mg/mL

Technique(s)

immunohistochemistry: 1:50- 1:200
western blot: 1:200-1:1000 (Cell Lysate)

Isotype

IgG

Numéro d'accès

NP_057698.2

Numéro d'accès UniProt

O95551

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TDP2(51567)

Description générale

Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22.

Spécificité

The antibody detects endogenous levels of total TDP2 protein.

Immunogène

Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2

Actions biochimiques/physiologiques

Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2).
Pommier Y, et al.
DNA Repair, 19, 114-129 (2014)
Ryuta Watanabe et al.
Molecular biology of the cell, 31(6), 478-490 (2020-01-23)
SPOP, speckle-type POZ protein is a substrate adaptor protein of the Cullin-3/RING ubiquitin E3 complex. The spop gene is the most commonly point mutated in human primary prostate cancers, but the pathological contribution of the SPOP mutations remains unclear. In
Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.
Zhou C, et al.
Bmb Reports, 46(2), 113-113 (2013)
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Gomez-Herreros F, et al.
Nature Communications, 8(1), 233-233 (2017)
Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
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