SAB4300606
Anti-LYVE1 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
Anti-CRSBP-1 antibody produced in rabbit, Anti-HAR antibody produced in rabbit, Anti-LYVE-1 antibody produced in rabbit, Anti-XLKD1 antibody produced in rabbit, Anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody produced in rabbit
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
~40 kDa
Espèces réactives
mouse, human, rat
Concentration
1 mg/mL
Technique(s)
western blot: 1:500-1:1000
Isotype
IgG
Séquence immunogène
(K-N-Q-Q-K)
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... LYVE1(10894)
Catégories apparentées
Description générale
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) is a type I integral membrane polypeptide. It is present on lymph vessel endothelial cells of both normal and neoplastic tissues. LYVE consists of a single N-terminal HA binding domain. It is mapped to human chromosome 11p15.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as CRSBP, is encoded by the gene localized on human chromosome 11p15.4. The encoded protein is mainly mapped to the plasma membrane as well as intracellular fibrillar structures in lymphatic endothelial cells (LECs), including primary human dermal LECs and SVEC4-10 cells. LYVE1 belongs to the link module superfamily of C-type lectins.
Immunogène
Peptide sequence around aa. 271-275 (K-N-Q-Q-K), according to the protein LYVE1.
Actions biochimiques/physiologiques
LYVE-1 (lymphatic vessel endothelial hyaluronan receptor 1) plays an important role in hyaluronan homeostasis. It controls cellular trafficking of the lymph nodes. It serves as an important lymphatic vessel marker.
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) induces activation of its ligand, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF)-A and hyaluronic acid, opens lymphatic intercellular junctions in vitro and in vivo by enhancing contraction of lymphatic endothelial cells (LECs). The encoded protein also facilitates uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes.
Caractéristiques et avantages
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Description de la cible
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Forme physique
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer
Bono P, et al.
Clinical Cancer Research, 10(21), 7144-7149 (2004)
Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium
Banerji S, et al.
The Journal of Biological Chemistry, 291(48), 25004-25018 (2016)
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
Banerji S, et al.
The Journal of Cell Biology, 144(4), 789-801 (1999)
Identification of a three-gene expression signature of poor-prognosis breast carcinoma
Bieche I, et al.
Molecular Cancer, 3(1), 37-37 (2004)
Romain Parent et al.
Biochemical and biophysical research communications, 450(1), 7-12 (2014-05-24)
The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner
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