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Key Documents

SAB4300504

Sigma-Aldrich

Anti-GJA1 (Ab-367) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-CX43 antibody produced in rabbit, Anti-DFNB38 antibody produced in rabbit, Anti-GJAL antibody produced in rabbit, Anti-ODDD antibody produced in rabbit, Anti-gap junction protein, alpha 1, 43kDa antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD00803532
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~43 kDa

Espèces réactives

rat, human, mouse

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(R-A-S-S-R)

Numéro d'accès NCBI

NP_000156.1

Numéro d'accès UniProt

P17302

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GJA1(2697)

Immunogène

Peptide sequence around aa. 365-369 (R-A-S-S-R), according to the protein GJA1.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Shane A Lloyd et al.
BMC musculoskeletal disorders, 15, 122-122 (2014-04-11)
Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by
Shane A Lloyd et al.
Bone, 57(1), 76-83 (2013-07-31)
Connexin 43 (Cx43) is a gap junction protein that plays an integral role in the skeletal response to mechanical loading and unloading. In a previous study, we demonstrated preservation of trabecular bone mass and cortical bone formation rate in mice
Alayna E Loiselle et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(1), 147-154 (2012-06-22)
Connexin43 (Cx43) plays an important role in osteoblastic differentiation in vitro, and bone formation in vivo. Mice with osteoblast/osteocyte-specific loss of Cx43 display decreased gap junctional intercellular communication (GJIC), bone density, and cortical thickness. To determine the role of Cx43
Richard A Lasher et al.
Journal of tissue engineering, 3(1), 2041731412455354-2041731412455354 (2012-08-25)
Quantifying structural features of native myocardium in engineered tissue is essential for creating functional tissue that can serve as a surrogate for in vitro testing or the eventual replacement of diseased or injured myocardium. We applied three-dimensional confocal imaging and
Jie Yu et al.
Molecular reproduction and development, 81(7), 666-675 (2014-04-23)
One of the most dynamic adult human tissues is the endometrium. Through coordinated, cyclical proliferation, differentiation, leukocyte recruitment, apoptosis, and desquamation, the uterine lining is expanded and shed monthly, unless pregnancy is established. Errors in these steps potentially cause endometrial
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