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SAB4300128

Sigma-Aldrich

Anti-phospho-NOS3 (pSer1177) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

ECNOS, NOS, NOSIII, eNOS

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About This Item

Numéro MDL:
MFCD00675266
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

predicted mol wt 133 kDa

Espèces réactives

mouse, rat, human

Concentration

1 mg/mL

Technique(s)

western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NP_000594.2

Numéro d'accès UniProt

P29474

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer1177)

Informations sur le gène

human ... NOS3(4846)

Immunogène

Peptide sequence around phosphorylation site of serine 1177 (T-Q-S(p)-F-S), according to the protein NOS3.

Application

Recommended dilutions
Western Blot 1:500 - 1:1000

Optimal dilutions should be determined by the user.

Actions biochimiques/physiologiques

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Payal Chakraborty et al.
Chemico-biological interactions, 313, 108821-108821 (2019-09-17)
Decrease in the bioavailability of vasoactive nitric oxide (NO), derived from the endothelial nitric oxide synthase (NOS3), underlines vascular endothelial damage. Our expanding knowledge on mature red blood cells (RBCs) makes it supposable that RBCs might contribute to vascular function
Contribution of eNOS variants to the genetic susceptibility of coronary artery disease in a Tunisian population.
Ben Ali M
Genetic Testing and Molecular Biomarkers, 19, 203-208 (2015)
Naoyuki Otani et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 41(11), 923-931 (2018-09-07)
This study was designed to investigate the effects of uric acid on vascular endothelial function in measurements carried out either at the bedside or the laboratory bench. First, we performed reactive hyperemia peripheral arterial tonometry using an EndoPAT 2000 device
Post-Transcriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Polypyrimidine Tract-Binding Protein 1.
Yi B
Arteriosclerosis, Thrombosis, and Vascular Biology, 35, 2153-2160 (2015)
Surfactant protein-D deficiency suppresses systemic inflammation and reduces atherosclerosis in ApoE knockout mice.
Hirano Y
Cardiovascular Research, 113, 1208-1218 (2017)
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