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SAB4200722

Sigma-Aldrich

Anti-Band 3 antibody, Mouse monoclonal

clone BIII-136, purified from hybridoma cell culture

Synonyme(s) :

AE 1, Anion exchange protein 1, Anion exchanger 1, Band 3 anion transport protein, Solute carrier family 4 member 1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Niveau de qualité

200

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

BIII-136, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

immunoblotting: 2-4 μg/mL (human erythrocytes ghosts extract)
immunoprecipitation (IP): suitable

Isotype

IgG2a

Numéro d'accès UniProt

P02730

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SLC4A1(6521)

Description générale

Anti-Band 3 antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the BIII-136 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with glycophorin B purified from human erythrocytes.

Application

Anti-Band 3 antibody, Mouse monoclonal may be used in immunoblotting and immunoprecipitation.

Actions biochimiques/physiologiques

As a response to an oxidative stress, Band 3 protein forms clusters and clear damaged and aged RBCs from circulation. Enhanced band 3 protein clustering is implicated in RBC disorders such as hemolytic anemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, malaria and sickle-cell disease.

Forme physique

Glycophorin B purified from human erythrocytes
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Akihiro Moriyama et al.
Scientific reports, 5, 17427-17427 (2015-12-01)
Membrane proteins interact with membrane lipids for their structural stability and proper function. However, lipid-protein interactions are poorly understood at a molecular level especially in the live cell membrane, due to current limitations in methodology. Here, we report that amphiphilic
Kodjo Ayi et al.
Blood, 104(10), 3364-3371 (2004-07-29)
High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous hemoglobin C (Hb-C), and glucose-6-phosphate dehydrogenase (G6PD) deficiency in regions with high incidence of Plasmodium falciparum malaria and case-control studies support the
Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion.
Giel J C G M Bosman et al.
Blood transfusion = Trasfusione del sangue, 8 Suppl 3, s48-s52 (2010-07-08)
Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion
Bosman G, et al.
Blood Transfusion = Trasfusione del Sangue, 8(Suppl 3), s48-s48 (2010)
J R Pawloski et al.
Nature, 409(6820), 622-626 (2001-02-24)
Previous studies support a model in which the physiological O2 gradient is transduced by haemoglobin into the coordinate release from red blood cells of O2 and nitric oxide (NO)-derived vasoactivity to optimize oxygen delivery in the arterial periphery. But whereas
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