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SAB4200230

Sigma-Aldrich

Anti-DPP4/CD26 antibody, Mouse monoclonal

clone A6H, purified from hybridoma cell culture

Synonyme(s) :

Monoclonal Anti-ADABP, Monoclonal Anti-ADCP2, Monoclonal Anti-DPPIV, Monoclonal Anti-TP103, Monoclonal Anti-dipeptidyl-peptidase 4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

A6H, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human

Concentration

~4.0 mg/mL

Technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
indirect immunofluorescence: 20-40 μg/mL using methanol/acetone fixed HT-29 cells

Isotype

IgG1

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... DPP4(1803)

Description générale

Monoclonal Anti-DPP4/CD26 (mouse IgG1 isotype) is derived from the hybridoma A6H produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human fetal homogenates. Dipeptidyl peptidase-4 (DPP4) belongs to the S9B protein family, which cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides and peptide hormones. It is a type II transmembrane glycoprotein, expressed on the surface of many cell types.

Immunogène

human fetal homogenates.

Application

Monoclonal Anti-DPP4/CD26 antibody produced in mouse has been used in:
  • enzyme linked immuno sorbent assay (ELISA)
  • immunocytochemistry
  • immunohistochemistry
  • flow cytometry

Actions biochimiques/physiologiques

Dipeptidyl peptidase-4 (DPP4) is involved in the regulation of the biological activity of hormones and chemokines, such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. DPP4 inhibition maybe used to treat type 2 diabetes mellitus. It acts as a T cell activation molecule and regulates immunity and immune-mediated disorders.

Forme physique

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
100M4869

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme
Matteucci E and Giampietro O
Current Medicinal Chemistry, 16(23), 2943-2951 (2009)
G M Hass et al.
Hybridoma, 20(4), 231-236 (2001-10-18)
The monoclonal antibody (MAb) A6H, originally developed to fetal renal tissues, was found to be highly reactive to renal cell carcinoma and was subsequently demonstrated to co-stimulate a subpopulation of T cells. The A6H antigen had not been identified heretofore.
R L Vessella et al.
Cancer research, 45(12 Pt 1), 6131-6139 (1985-12-01)
Monoclonal antibodies (MABs) reactive with human renal cell carcinoma (RCC) were generated following immunization of mice with either RCC homogenates, RCC cell lines, or fetal kidney homogenates. The characteristics of four highly reactive immunoglobulin G1 MABs, designated UMVA-RCC-A6H, UMVA-RCC-A36, UMVA-RCC-C5H

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