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SAB3500576

Sigma-Aldrich

Anti-MFSD2A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Mfsd2A Antibody, Mfsd2A Antibody - Anti-MFSD2A antibody produced in rabbit, Anti-Major facilitator superfamily domain-containing protein 2A, Anti-mfsd2aa

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, rat, human

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

NP_001007452

Numéro d'accès UniProt

Q5U3U7

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

zebrafish ... mfsd2aa(492810)

Description générale

Major facilitator superfamily domain containing 2a (Mfsd2a)is a sodium-dependent lysophosphatidylcholine (LPC) transporter. The endothelium of the micro vessels in blood brain barrier express high levels of Mfsd2a.

Immunogène

MFSD2A antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MFSD2A.

Actions biochimiques/physiologiques

Major facilitator superfamily domain containing 2a (Mfsd2a) acts as a transporter for the essential omega-3 fatty acid docosahexaenoic acid. It is essential at the blood-brain barrier for postnatal brain growth. A leaky blood-brain barrier from embryonic stages through to adulthood is observed if there is a genetic variation in this gene. Mutation in MFSD2A gene results in microcephaly and ventriculomegaly.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3500576.

Forme physique

Supplied in PBS with 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain
Chan JP, et al.
PLoS Biology, 16(8), e2006443-e2006443 (2018)
Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Cause a Lethal Microcephaly Syndrome
Guemez-GA, et al.
Nature Genetics, 47(7), 809-809 (2015)
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
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