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Key Documents

SAB2500042

Sigma-Aldrich

Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-AIF-1, Anti-Allograft inflammatory factor 1, Anti-DASS-82G15.2, Anti-IBA1, Anti-IRT-1

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About This Item

Numéro MDL:
MFCD02685938
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, rat, human

Technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

P55008

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... AIF1(199)

Catégories apparentées

Description générale

AIF1 (allograft inflammatory factor 1) is a calcium-binding, cytoplasmic protein that has 143-amino acids. It is also known as IBA1 (ionized calcium-binding adapter molecule 1). It is expressed in the cells of the monocyte/macrophage lineage, as well as in microglial and dendritic cells. It is located on human chromosome 6p21.3.

Immunogène

Peptide with sequence C-NKQFLDDPKYSSDED from the internal region of the protein sequence according to NP_001614.3.

Application

Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat has been used in western blotting and immunofluorescence.

Actions biochimiques/physiologiques

AIF1 (allograft inflammatory factor 1) is an essential factor of macrophage chemotaxis. Expression of AIF1 regulates the proliferation of vascular smooth muscle cells by G-CSF (cytokine granulocyte-colony stimulating factor) autocrine expression.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Inhibition of AIF-1 expression by constitutive siRNA expression reduces
macrophage migration, proliferation, and signal transduction initiated by
atherogenic stimuli.
Ying T, et al.
American Journal of Physiology. Cell Physiology (2005)
dolescent binge alcohol exposure affects the brain function through mitochondrial impairment
Tapia-Rojas C, et al.
Molecular Neurobiology, 55, 4473-4491 (2018)
Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation.
Arnulf H K, et al.
Acta Neuropathologica Communications, 4(1), 46-46 (2016)
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Wang Q, et al.
Cancer Cell, 32(1), 42-56 (2017)
Juciano Gasparotto et al.
Brain, behavior, and immunity, 62, 124-136 (2017-01-16)
Systemic inflammation induces transient or permanent dysfunction in the brain by exposing it to soluble inflammatory mediators. The receptor for advanced glycation endproducts (RAGE) binds to distinct ligands mediating and increasing inflammatory processes. In this study we used an LPS-induced
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