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Key Documents

SAB1306281

Sigma-Aldrich

ANTI-SNAIL (N-TERM D24) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Protein snail homolog 1, SNAH, SNAI1, Zinc finger protein SNAI1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

29083 Da

Espèces réactives

human

Technique(s)

immunohistochemistry: 1:10-1:50
western blot: 1:1000

Numéro d'accès NCBI

Numéro d'accès UniProt

Application(s)

research pathology

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SNAI1(6615)

Description générale

Snail family transcriptional repressor 1 (SNAIL) is a transcription factor and the gene encoding it is localized on human chromosome 20q13.13.

Application

ANTI-SNAIL (N-TERM D24) antibody produced in rabbit has been used in Western Blotting.

Actions biochimiques/physiologiques

Snail family transcriptional repressor 1 (SNAIL) acts as a repressor of genes associated with the epithelial phenotype like E-cadherin and increases the expression of genes linked with the mesenchymal phenotype. It has a role in epithelial-mesenchymal transition. The protein aids in G1 transition (early to late) in the cell cycle. SNAIL also modulates cell-matrix adhesion.

Forme physique

Supplied in PBS with 0.09% (W/V) sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Biochanin A extirpates the epithelial-mesenchymal transition in a human lung cancer
Wang Yan
Experimental and Therapeutic Medicine, 2830-2836 (2018)
CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells.
Haraguchi M
PLoS ONE, 10(7) (2015)
SNAIL transcription factor increases the motility and invasive capacity of prostate cancer cells.
Osorio LA
Molecular Medicine Reports, 13(1), 778-786 (2016)
TP53 Mutation, Epithelial-Mesenchymal Transition, and StemlikeFeatures in Breast Cancer Subtypes
Danila Coradini
Journal of Biomedicine and Biotechnology (2013)
Yan Wang et al.
Experimental and therapeutic medicine, 15(3), 2830-2836 (2018-02-20)
The natural iso-flavonoid, biochanin A, is categorized as a phytoestrogen and has been demonstrated to exhibit various pharmacological properties. However, no effects of biochanin A on lung cancer cell lines have been reported. Therefore, the present study aimed to demonstrate

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