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R6527

Sigma-Aldrich

Reboxetine mesylate hydrate

>96% (HPLC), solid

Synonyme(s) :

(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra

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About This Item

Formule empirique (notation de Hill):
C19H23NO3 · CH3SO3H · xH2O
Numéro CAS:
98769-84-7
Poids moléculaire :
409.50 (anhydrous basis)
Numéro MDL:
MFCD11046031
Code UNSPSC :
12352200
ID de substance PubChem :
24724592
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

>96% (HPLC)

Forme

solid

Conditions de stockage

desiccated

Couleur

white to tan

Solubilité

H2O: >5 mg/mL at ≤60 °C

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Chaîne SMILES 

O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3

InChI

1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1

Clé InChI

SZPHEVAYLIVGRC-BAMQSBMESA-N

Application

Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
  • to study its effects on the surge of dopamine in the cortex of mice brain
  • to study its anti-immobility effects on the behavior of mice
  • to analyze its effects on the probabilistic reversal learning task in rodents

Actions biochimiques/physiologiques

Reboxetine exhibits anti-depressant activity.
Selektiver Noradrenalin-Aufnahme-Inhibitor

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

S Kasper et al.
Expert opinion on pharmacotherapy, 1(4), 771-782 (2001-03-16)
Several treatment approaches are available for treatment of depression. However, reboxetine is the first selective noradrenaline re-uptake inhibitor. Whereas formerly only noradrenaline re-uptake inhibitors with a mixed mechanism of action were available. These included action not only at noradrenergic, but
Hagar Gelbard-Sagiv et al.
Current biology : CB, 28(14), 2239-2249 (2018-07-10)
An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share
Charlotte J W Connell et al.
Medicine and science in sports and exercise, 49(9), 1778-1788 (2017-04-30)
Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the
Kristine Chobanyan-Jürgens et al.
Scientific reports, 8(1), 7748-7748 (2018-05-19)
Clinical trials and studies with ivabradine implicate cardiac pacemaker channels (HCN4) in the pathogenesis of atrial arrhythmias. Because acute changes in cardiac autonomic tone predispose to atrial arrhythmias, we studied humans in whom profound cardiac sympathetic activation was rapidly relieved
J M Kent
Lancet (London, England), 355(9207), 911-918 (2001-02-07)
A major goal of antidepressant development is to improve on preceding drug classes with agents with greater specificity (and therefore fewer unwanted side-effects) and with more rapid onset of antidepressant action. To this end, four antidepressants with significantly distinct pharmacological
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