R4528

Anti-hnRNP-A1 antibody, Mouse monoclonal

clone 9H10, purified from hybridoma cell culture

• Synonyme(s) : Anti-heterogeneous nuclear ribonucleoprotein-A1
• Numéro MDL: MFCD06798702
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 9H10, monoclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~34 kDa
• Espèces réactives: human, hamster, monkey, rat, bovine, mouse, canine
• Technique(s): immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; microarray: suitable; western blot: 0.5-1.0 μg/mL using total cell extract of 293T cells
• Isotype: IgG2b
• Numéro d'accès UniProt: P09651
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... HNRNPA1(3178) ; mouse ... Hnrnpa1(15382) ; rat ... Hnrnpa1(29578)

Description

Description générale

hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) is a pre-mRNA/mRNA binding protein, that belongs to the hnRNP family. It is located in chromosome 12q13.1. It is located in the nucleoplasm but it travels between the nucleus and the cytoplasm. It has two RNP motif RNA-binding domains (RBDs) at the amino terminus and a glycine-rich domain at the carboxyl terminus.

Immunogène

purified human hnRNP-A1.

Application

Anti-hnRNP-A1 has been used in immunofluorescence, immunohistochemistry and western blotting.

Does not immunoprecipitate the hnRNP complex.

Actions biochimiques/physiologiques

hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) participates in several RNA metabolisms. It also participates in deep vein thrombosis patients with behçet′s disease. hnRNPA1 mutations results in amyotrophic lateral sclerosis and multisystem proteinopathy.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable