PZ0159

MCOPPB trihydrochloride hydrate

>98% (HPLC)

• Synonyme(s) : 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate
• Formule empirique (notation de Hill): C₂₆H₄₀N₄ · 3 HCl · xH₂O
• Numéro CAS: 1028969-49-4
• Poids moléculaire : 518.01 (anhydrous basis)
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823741
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: >98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: H₂O: ≥13 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5
• InChI: 1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2
• Clé InChI: UQBVSGBDJOJHIP-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

Caractéristiques et avantages

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable