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Key Documents

PRS3141

Sigma-Aldrich

Anti-TLR4 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Toll-like receptor 4

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About This Item

Numéro MDL:
MFCD03455299
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

predicted mol wt 92 kDa

Espèces réactives

human

Technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

O00206

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TLR4(7099)

Description générale

Toll-like receptors (TLRs) are transmembrane receptors expressed on the surface of immune and non-immune cells. There are at least 13 different TLRs identified that mediate signalling pathways contributing to acute inflammatory processes during tissue damage and bacterial infections TLR2 is highly inducible by numerous inflammatory mediators resulting in translocation of transcription factor NF-κB-mediated proinflammatory cytokines and immune responses

Immunogène

a peptide corresponding to 15 amino acids near the amino-terminus of human TLR4.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3141.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Shneh Sethi et al.
Virulence, 2(4), 316-328 (2011-07-16)
Recent studies in murine models of Staphylococcus aureus (S. aureus) infection have investigated the association of Toll-like receptor (TLR)2, TLR4, myeloid differentiation factor 88 (MyD88) and Nod-like receptor (NOD)2 with the production of cytokines / chemokines and their involvement in
Emmanuel Lorne et al.
Intensive care medicine, 36(11), 1826-1835 (2010-08-07)
Although the role of Toll-like receptors (TLRs) in bacterial infection and sepsis is well characterized, recent studies have also shown that TLR4 and TLR2 can play an important role in contributing to acute inflammatory processes and organ dysfunction in settings
Amanda Croasdell et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(9), 3181-3193 (2016-06-04)
TLRs are critical for innate immunity, but excessive activation can lead to tissue damage and disease. Specialized proresolving mediators (SPMs), including resolvin D2 (RvD2), promote the active resolution of inflammation. How SPMs regulate early LPS signaling, including activation of TLR4
Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis
Wittebole X et al
Mediators of Inflammation, doi: 10-doi: 10 (2010)
Xueqin Huang et al.
International immunopharmacology, 22(1), 266-272 (2014-07-17)
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by various immunological abnormalities. Dihydroartemisinin (DHA), a metabolite of artemisinin, has been recently reported to exhibit immunosuppressive properties. The present study aims to determine the effects of DHA on spleen
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