PRS1112

Anti-CCR5 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonyme(s) : Anti-Chemokine (C-C motif) receptor 5
• Numéro MDL: MFCD01864608
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: IgG fraction of antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: predicted mol wt 39 kDa
• Espèces réactives: human
• Technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Numéro d'accès UniProt: P51681
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CCR5(1234)

Description

Description générale

C-C motif chemokine receptor 5 (CCR5) is expressed by T lymphocytes, macrophages and monocytes. It belongs to the chemokine receptor family. The gene encoding this protein is localized on human chromosome 3p21.31.

Immunogène

a peptide corresponding to amino acids 6-20 of human CCR5.

Actions biochimiques/physiologiques

C-C motif chemokine receptor 5 (CCR5) is a receptor for chemokine ligands-3, -4 and -5. It acts as a co-receptor for human immunodeficiency virus (HIV) entry in cells.The protein also has a role in leukocyte chemotaxis. CCR5 indirectly influence the aggregation of immune cells at the site of viral infection on mucosal surfaces. It also modulates activation of immune cells during inflammation.

Liaison

The action of this antibody can be blocked using blocking peptide SBP1112.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable