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Principaux documents

PLA0236

Sigma-Aldrich

Anti-KRAS Antibody

from rabbit

Synonyme(s) :

ERK, ERK-2, ERK2, ERT1, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MAPK 2, MAPK2, P42MAPK, PRKM1, PRKM2, extracellular signal-regulated kinase 2, mitogen-activated protein kinase 2, p38, p40, p41, p41mapk, p42-MAPK, protein tyrosine kinase ERK2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Nom du produit

Rabbit anti-ERK2 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Qualité

Powered by Bethyl Laboratories, Inc.

Espèces réactives

human, mouse

Technique(s)

immunohistochemistry: 1:500- 1:2,000
western blot: 1:2,000- 1:10,000

Numéro d'accès

NP_002736.3

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Informations sur le gène

rabbit ... ERK2(5594)

Immunogène

The epitope recognized by PLA0236 maps to a region between residue 310 and 360 of human extracellular signal-regulated kinase-2 (mitogen-activated protein kinase 1) using the numbering given in entry NP_002736.3 (GeneID 5594).

Forme physique

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Autres remarques

Extracellular signal-regulated kinase 2 (ERK2/p42) is also known as mitogen-activated protein kinase 1 (MAPK1). ERK2 is part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK2 is very similar in sequence to ERK1/p44 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Gwendolyn I Humphreys et al.
PloS one, 9(11), e111975-e111975 (2014-11-06)
17β-estradiol (E2) plays critical roles in a number of target tissues including the mammary gland, reproductive tract, bone, and brain. Although it is clear that E2 reduces inflammation and ischemia-induced damage in the cerebral cortex, the molecular mechanisms mediating the
Cynthia L Neben et al.
Human molecular genetics, 23(21), 5659-5671 (2014-06-09)
Fibroblast growth factor receptor 2 (FGFR2) promotes osteoprogenitor proliferation and differentiation during bone development, yet how the receptor elicits these distinct cellular responses remains unclear. Analysis of the FGFR2-skeletal disorder bent bone dysplasia syndrome (BBDS) demonstrates that FGFR2, in addition
Ji-Hee Kim et al.
Oncology reports, 31(6), 2708-2712 (2014-05-03)
Protein tyrosine kinase 7 (PTK7) is a catalytically inactive receptor tyrosine kinase that is also known as colon carcinoma kinase-4 (CCK-4). Recent reports have shown that PTK7 plays an important role in carcinogenesis, and it is known to be upregulated
K A Hlavaty et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(7), 1523-1532 (2014-06-10)
Islet transplantation represents a potential cure for type 1 diabetes, yet the clinical approach of intrahepatic delivery is limited by the microenvironment. Microporous scaffolds enable extrahepatic transplantation, and the microenvironment can be designed to enhance islet engraftment and function. We
Tetsuo Mashima et al.
Cancer research, 74(17), 4888-4897 (2014-06-26)
Endocrine therapy is the standard treatment for advanced prostate cancer; however, relapse occurs in most patients with few treatment options available after recurrence. To overcome this therapeutic hurdle, the identification of new molecular targets is a critical issue. The capability
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