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Principaux documents

PLA0179

Sigma-Aldrich

Rabbit anti-NBS1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonyme(s) :

AT-V1, AT-V2, ATV, NBS, NBS1, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, P95, cell cycle regulatory protein p95, p95 protein of the MRE11/RAD50 complex

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Qualité

Powered by Bethyl Laboratories, Inc.

Espèces réactives

human

Technique(s)

immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

Numéro d'accès

NP_002476.2

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Informations sur le gène

rabbit ... NBS1(4683)

Immunogène

The epitope recognized by PLA0179 maps to a region between residue 704 and 754 of human Nibrin using the numbering given in entry NP_002476.2 (GeneID 4683).

Forme physique

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Autres remarques

Mutations in NBS1 (Nijmegen Breakage Syndrome 1), also known as nibrin, are associated with the autosomal recessive syndrome, Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. At the cellular level, NBS1 is part of the MRE11/RAD50 double-strand break repair complex that is critical to the DNA damage response, DNA recombination, telomere integrity, and cell cycle checkpoint control.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Yuki Yamamoto et al.
Cancer research, 74(14), 3707-3715 (2014-05-17)
Failure to expeditiously repair DNA at sites of double-strand breaks (DSB) ultimately is an important etiologic factor in cancer development. NBS1 plays an important role in the cellular response to DSB damage. A rare polymorphic variant of NBS1 that resulted
Bárbara Alcaraz Silva et al.
The Journal of biological chemistry, 289(33), 22771-22784 (2014-07-02)
Chromosome ends contain nucleoprotein structures known as telomeres. Damage to chromosome ends during interphase elicits a DNA damage response (DDR) resulting in cell cycle arrest. However, little is known regarding the signaling from damaged chromosome ends (designated here as "TIPs")
Eui Young So et al.
Cancer biology & therapy, 15(7), 906-910 (2014-04-24)
The bone marrow (BM) is one of the organs that is sensitive to acute exposure of ionizing radiation (IR); however, the mechanism of its high sensitivity to IR remains to be elucidated. BM is differentiated into dendritic cells (DC) with

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