P9386

Poly-L-histidine

mol wt 5,000-25,000

• Synonyme(s) : L-Histidine homopolymer
• Numéro CAS: 26062-48-6
• Numéro MDL: MFCD00166382
• Code UNSPSC : 12352209
• ID de substance PubChem : 24899031
• Nomenclature NACRES : NA.26

Propriétés

• Forme: powder or solid
• Poids mol.: 5,000-25,000
• Couleur: white to light yellow
• Application(s): cell analysis
• Température de stockage: −20°C
• InChI: 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
• Clé InChI: HNDVDQJCIGZPNO-YFKPBYRVSA-N

Description

Description générale

Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.

Application

Poly-L-histidine has been used:

• as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
• as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
• in screening its anti-prion activity in cell based and in vivo anti-prion assay

Actions biochimiques/physiologiques

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

Remarque sur l'analyse

Molecular weight by MALLS.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)