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Key Documents

P1742

Sigma-Aldrich

Prealbumin from human plasma

lyophilized powder

Synonyme(s) :

Thyroxine binding prealbumin, Transthyretin

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About This Item

Numéro CAS:
87090-18-4
Numéro MDL:
MFCD00132069
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.25

Source biologique

human plasma

Niveau de qualité

200

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Technique(s)

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

Solubilité

H2O: soluble 1 mg/mL

ε (coefficient d'extinction)

13.5 at 280 nm at 1%

Numéro d'accès UniProt

P02766

Température de stockage

−20°C

Informations sur le gène

human ... TTR(7276)

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Catégories apparentées

Description générale

Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.

Application

Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.
Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.

Actions biochimiques/physiologiques

Human prealbumin has been observed in carcinoid tumors.
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).

Conditionnement

Package size based on protein content

Forme physique

Lyophilized powder containing sodium phosphate and NaCl

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Serum albumin and prealbumin in calorically restricted, nondiseased individuals: a systematic review
Lee JL, et al
The American Journal of Medicine, 128(9), 1023-e1-1023-e1 (2015)
K Tashima et al.
Journal of the neurological sciences, 171(1), 19-23 (1999-11-24)
Since 1990, liver transplantation for familial amyloidotic polyneuropathy (FAP) has been carried out world-wide, and the outcome of the procedure seems to be promising. FAP is inherited systemic disease caused by mutated transthyretin. The most common cause is the valine
Gen Sobue
Rinsho shinkeigaku = Clinical neurology, 43(11), 769-774 (2004-05-22)
A nationwide study of CMT and FAP has been performed. In FAP TTR Met30 families with late onset, neuropathy showed male preponderance, low penetrance, little relationship to endemic foci, sensorimotor symptoms beginning distally in the lower extremities with disturbance of
J Figueras et al.
Medicina clinica, 116(10), 377-379 (2001-05-03)
Domino or sequential liver transplantation (DTXL) is a kind of living donor transplant, which was proposed in 1993 and performed for the first time in 1995; later on, more than 45 have been reported. The liver from a patient with
David Adams et al.
Presse medicale (Paris, France : 1983), 41(9 Pt 1), 793-806 (2012-02-22)
The treatment of familial amyloid polyneuropathies (FAP) is complex and requires a neurological and cardiological multidisciplinary coverage. It includes specific treatments to control the progression of the systemic amyloidogenesis, the symptomatic treatment of the peripheral and autonomic neuropathy (digestive, urinary
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