P1034

Phenyl isothiocyanate

Sigma Grade, 8.36 M, suitable for solid phase protein sequencing analysis, ≥99% (GC), liquid

• Synonyme(s) : PITC
• Formule linéaire : C₆H₅NCS
• Numéro CAS: 103-72-0
• Poids moléculaire : 135.19
• Beilstein: 471392
• Numéro CE : 203-138-1
• Numéro MDL: MFCD00004798
• Code UNSPSC : 12352118
• ID de substance PubChem : 24898144
• Nomenclature NACRES : NA.31

Propriétés

• Qualité: Sigma Grade
• Niveau de qualité: 100
• Essai: ≥99% (GC)
• Forme: liquid
• Concentration: 8.36 M
• Indice de réfraction: n20/D 1.6515 (lit.)
• pb: 218 °C (lit.)
• Pf: −21 °C (lit.)
• Densité: 1.132 g/mL at 20 °C (lit.)
• Adéquation: suitable for solid phase protein sequencing analysis
• Température de stockage: 2-8°C
• Chaîne SMILES: S=C=Nc1ccccc1
• InChI: 1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H
• Clé InChI: QKFJKGMPGYROCL-UHFFFAOYSA-N

Description

Description générale

Phenyl isothiocyanate belongs to the class of aromatic compounds with isothiocyanate groups. It is typically used as a precolumn derivatization agent for the formation of phenylthiocarbamyl amino acids for their subsequent determination using chromatography techniques.

Application

Phenyl isothiocyanate may be used in the polypeptide and protein sequencing at the subpicomole and subnanomole levels, respectively, by applying automated Edman chemistry followed by the analysis using high-performance liquid chromatography (HPLC) technique.

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

Conditionnement

One mL size packaged in flame sealed amber ampules under argon.
Ten mL size packaged in screw cap amber vials under argon.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H301,H314,H317,H334
• Conseils de prudence: P261 - P272 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 190.4 °F - closed cup
• Point d'éclair (°C): 88 °C - closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter