P0036

PP121

≥98% (HPLC)

• Synonyme(s) : 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• Formule empirique (notation de Hill): C₁₇H₁₇N₇
• Numéro CAS: 1092788-83-4
• Poids moléculaire : 319.36
• Numéro MDL: MFCD12912434
• Code UNSPSC : 12352200
• ID de substance PubChem : 329819987
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5
• InChI: 1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
• Clé InChI: NVRXTLZYXZNATH-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events. It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable