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Key Documents

N4413

Sigma-Aldrich

Anti-Nanog antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-FLJ12581, Anti-Nanog homeobox

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

western blot: 1:1,000-1:2,000

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NANOG(79923)
mouse ... Nanog(71950)
rat ... Nanog(414065)

Description générale

Nanog homeobox (NANOG) is a 305 amino acid transcription factor. It is expressed in many types of cancers.

Immunogène

synthetic peptide corresponding to an internal sequence of human Nanog.

Actions biochimiques/physiologiques

Nanog homeobox (NANOG) works with pluripotency factors like sex determining region Y-box 2 (SOX2). It is involved in conserving the pluripotency and self-renewal properties of embryonic stem cells. NANOG also associates with the c-Jun promoter.

Forme physique

solution in phosphate buffered saline, containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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NANOG upregulates c-Jun oncogene expression through binding the c-Jun promoter.
Lin Y
Molecular Carcinogenesis, 54(11), 1407-1416 (2015)
Shuai Gong et al.
Molecular carcinogenesis, 54(9), 679-687 (2015-05-28)
As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self-renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi Y
Proceedings of the National Academy of Sciences of the USA, 112(15), 4666-4671 (2015)
Yongyu Wang et al.
Biomaterials, 35(32), 8960-8969 (2014-08-03)
Tissue-engineered blood vessels (TEBVs) are promising in the replacement of diseased vascular tissues. However, it remains a great challenge to obtain a sufficient number of functional smooth muscle cells (SMCs) in a clinical setting to construct patient-specific TEBVs. In addition
Miriama Krutá et al.
Stem cells and development, 23(20), 2443-2454 (2014-05-20)
The genomic destabilization associated with the adaptation of human embryonic stem cells (hESCs) to culture conditions or the reprogramming of induced pluripotent stem cells (iPSCs) increases the risk of tumorigenesis upon the clinical use of these cells and decreases their

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