MTOXCE2D6
CypExpress™ 2D6 Cytochrome P450 human
Synonyme(s) :
CPD6, CYP2D, CYP2D6, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450 2D6, P450-DB1, P450C2D, P450DB1
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About This Item
Source biologique
human
Produit recombinant
expressed in Pichia pastoris
Forme
dry powder
Numéro d'accès UniProt
Application(s)
cell analysis
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... CYP2D6(1565)
Application
Poster: A Novel, Robust Recombinant Human P450 Biocatalytic System
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Actions biochimiques/physiologiques
Cytochrome P450 enzymes are heme containing monooxygenases which are found primarily in the mammalian liver. They catalyze the oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. Quinidine is an inhibitor, whereas there is no known effective inducer of the enzyme. The isozyme CYP2D6 is a major pathway for the invivo conversion of dextromethorphan to dextrorphan via O-demethylation.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.
Caractéristiques et avantages
CypExpress™ 2D6 is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 2D6 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress™ are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress™ retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems. It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.
Définition de l'unité
A reaction mixture containing 1 mM dextromethorphan and 100 mg/mL of CypExpress™ 2D6 will produce 268.8 μM dextrorphan in 4 hours at 30°C under the conditions described.
Forme physique
Light yellow, very fine powder
Reconstitution
Per Protocol/Variable
Informations légales
6538 is a trademark of American Type Culture Collection
CypExpress is a trademark of Oxford Biomedical Research
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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