MAK203

DPP4 INHIBITOR SCREENING KIT

Sufficient for 100 Fluorometric tests

• Synonyme(s) : Adenosine Deaminase Complexing Protein-2 Inhibitor Screening Kit, CD26 Inhibitor Screening Kit, Dipeptidyl-Peptidase 4 Inhibitor Screening Kit
• Code UNSPSC : 12161503
• Nomenclature NACRES : NA.25

Propriétés

• Application(s): pharmaceutical
• Méthode de détection: fluorometric
• Maladie(s) pertinente(s): endocrinological disorders, diabetes
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... DPP4(1803) ; mouse ... DPP4(13482) ; rat ... DPP4(25253)

Description

Description générale

Dipeptidyl-peptidase 4 (DPP4; CD26; adenosine deaminase complexing protein-2) is a membrane glycoprotein with serine exopeptidase activity that cleaves X-proline dipeptides from the N-terminus of polypeptides. Inhibitors of DPP4 inhibit the degradation of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4 and have emerged as oral anti-diabetic agents.

Caractéristiques et avantages

Compatible with high-throughput handling systems.

Adéquation

Suitable for the screening of inhibitors of DPP4.

Principe

The DPP4 Inhibitor Screening Kit is a simple assay suitable for high-throughput screening of potential DPP4 inhibitors. DPP4 activity is measured by cleaving the substrate to yield a fluorescent product (λ_ex = 360/λ_em = 460 nm), proportional to the enzymatic activity present. The effectiveness of the test inhibitors may be compared with the DPP4 inhibitor (sitagliptin) provided as a control.

Composants de kit seuls

• DPP4 Assay Buffer
• DPP4 Substrate
• DPP4 Enzyme
• DPP4 Inhibitor, Sitagliptin

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): 188.6 °F - closed cup
• Point d'éclair (°C): 87 °C - closed cup