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Key Documents

M3895

Sigma-Aldrich

Mucin from bovine submaxillary glands

Type I-S

Synonyme(s) :

MUC

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About This Item

Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine submaxillary glands

Niveau de qualité

Type

Type I-S

Forme

powder

Composition

Bound sialic acids, 9-24%

Technique(s)

electrophoresis: suitable

Numéro d'accès UniProt

Température de stockage

−20°C

Informations sur le gène

cow ... BSM(286841)

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Catégories apparentées

Description générale

Mucin from bovine submaxillary glands is encoded by two bovine submaxillary BSM genes. It is present in the saliva and interacts with air and food. Mucin comprises three major domains namely N- and C terminal and the glycosylated proline, threonine and serine (PTS domain) central domain. The sialic acid contributes to 30% of the molecular weight of mucin. The central domain has many tandem repeats.

Application

Mucin from bovine submaxillary glands has been used:
  • in the quantification of mucin
  • as a component of artificial tear solution
  • as a substrate for recombinant sialidase Gardnerella vaginalis
  • to investigate a galactose-specific lectin from the red marine alga Ptilota filicina
  • to study the characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa)

Actions biochimiques/physiologiques

Bovine submaxillary mucin (BSM) is thermally stable up to 85°C. The terminal domain regions are key for the adsorption functionality of mucin.
Albuminoid substance in mucus which gives it its ropy consistency

Liaison

Similar to M 4503, but produced by Sigma.

Substrats

Neuraminidase substrate.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Identification and characterization of NanH2 and NanH3, enzymes responsible for sialidase activity in the vaginal bacterium Gardnerella vaginalis
Robinson LS, et al.
Test, 294(14), 5230-5245 (2019)
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium
Brookes DM, et al.
British Journal of Pharmacology, 175(12), 2520-2534 (2018)
Sasi B Yarragudi et al.
Carbohydrate polymers, 163, 216-226 (2017-03-08)
Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and nasal clearance. Recent modelling data indicates that 10μm-sized microparticles
S Goswami et al.
Experimental lung research, 20(1), 85-100 (1994-01-01)
A human endometrial adenocarcinoma cell line (Ishikawa) has been shown to incorporate [3H]glucosamine and to secrete a radiolabeled high molecular weight compound which is excluded from a Sepharose CL-2B column. The excluded material was resistant to hyaluronidase, chondroitinase ABC, and
Instability and breakup of model tear films
Bhamla MS, et al.
Investigative Ophthalmology & Visual Science, 57(3), 949-958 (2016)

Articles

Review article and products for sialic acid synthesis and signaling.

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