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Key Documents

K2628

Sigma-Aldrich

Ketotifen fumarate salt

≥99% (TLC), powder, H₁ histamine receptor antagonist

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About This Item

Formule empirique (notation de Hill):
C19H19NOS · C4H4O4
Numéro CAS:
34580-14-8
Poids moléculaire :
425.50
Numéro CE :
252-100-0
Numéro MDL:
MFCD00079394
Code UNSPSC :
12352200
ID de substance PubChem :
24278506
Nomenclature NACRES :
NA.77

product name

Ketotifen fumarate salt,

Forme

powder

Niveau de qualité

100

Auteur

Novartis

Chaîne SMILES 

OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24

InChI

1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

Clé InChI

YNQQEYBLVYAWNX-WLHGVMLRSA-N

Informations sur le gène

human ... HRH1(3269) , PDE7B(27115)

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Description générale

Ketotifen fumarate salt is an antihistamine drug.

Application

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Actions biochimiques/physiologiques

H1 histamine receptor antagonist.
Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells
Yamada P, et al.
Journal of Ethnopharmacology, 116(2), 279-287 (2008)
Yongzheng Min et al.
The Journal of surgical research, 171(2), e193-e199 (2011-10-04)
To investigate the effects of imatinib (Glivec) on the urinary bladder contraction and excitation induced by neurostimulation, therefore to clarify the relationships between the bladder interstitial cell of Cajal (ICC) and the neural signals. In in vivo experiments, pelvic nerves of
Investigation into the mechanism of action of Moringa oleifera for its anti-asthmatic activity
Mehta A and Agrawal B
Oriental Pharmacy and Experimental Medicine, 8(1), 24-31 (2008)
Jing Wang et al.
Diabetes/metabolism research and reviews, 27(8), 919-924 (2011-11-10)
Mast cells are essential in allergic responses and beyond. White adipose tissue from obese humans contains large numbers of mast cells. Serum mast cell tryptase levels are also significantly higher in obese subjects than in lean subjects, suggesting a role
A Tieppo et al.
Journal of controlled release : official journal of the Controlled Release Society, 157(3), 391-397 (2011-10-11)
In this paper, we demonstrate the successful in vivo extended release of a small molecular weight therapeutic, ketotifen fumarate (MW=425), from molecularly imprinted, therapeutic contact lenses. This is the first time that a steady, effective concentration of drug is maintained
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