J4649

JNJ-10198409

≥98% (HPLC), solid

• Synonyme(s) : 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine, RWJ 540973
• Formule empirique (notation de Hill): C₁₈H₁₆FN₃O₂
• Numéro CAS: 627518-40-5
• Poids moléculaire : 325.34
• Code UNSPSC : 51111800
• ID de substance PubChem : 329815736
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: off-white
• Solubilité: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• Auteur: Johnson & Johnson
• Température de stockage: −20°C
• Chaîne SMILES: COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC
• InChI: 1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)
• Clé InChI: ZDNURMVOKAERHZ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC₅₀ values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PAF Receptor and PDGFR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable