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Merck
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I9898

Sigma-Aldrich

Anti-Interleukin-5 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonyme(s) :

Anti-IL-5

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About This Item

Numéro MDL:
MFCD00212216
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

human

Technique(s)

indirect ELISA: 0.5-1.0 μg/test
neutralization: suitable
western blot: 1-2 μg/mL

Numéro d'accès UniProt

P05113

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... IL5(3567)

Description générale

The antibody neutralizes the biological activity of recombinant human IL-5.

Immunogène

recombinant human IL expressed in Sf 21 insect cell line.

Actions biochimiques/physiologiques

Interleukin-5 is a T-cell derived cytokine that induces the differentiation of B cells into antibody producing plasma cells. It is a critical differentiation factor for eosinophils and regulates the expression of genes required for cell proliferation, survival and maturation. The cellular functions of IL-5 are mediated by JAK-STAT, Btk and Ras/Raf-ERK signaling pathways. IL-5 is a good molecular target for the treatment of eosinophilic diseases.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Notes préparatoires

Purified using protein G.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Taku Kouro et al.
International immunology, 21(12), 1303-1309 (2009-10-13)
IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation into antibody-secreting plasma cells, at least in mice. Concurrently, IL-5 was recognized as the major maturation and differentiation factor for eosinophils in mice and
Kiyoshi Takatsu
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(8), 463-485 (2011-10-12)
While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells including B cells, eosinophils, and basophils.
Jonathan Corren
Discovery medicine, 13(71), 305-312 (2012-05-01)
Elevated numbers of blood and tissue eosinophils are present in allergic diseases and experimental evidence suggests that eosinophils play an important pathogenic role in these conditions. Regulation of eosinophil maturation, recruitment, and survival is under the control of a small
Patricia C Fulkerson et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4043-4052 (2014-09-19)
Eosinophils originate in the bone marrow from an eosinophil lineage-committed, IL-5Rα-positive, hematopoietic progenitor (eosinophil progenitor). Indeed, IL-5 is recognized as a critical regulator of eosinophilia and has effects on eosinophil progenitors, eosinophil precursors, and mature eosinophils. However, substantial levels of
Qiong Long et al.
Human vaccines & immunotherapeutics, 10(8), 2303-2311 (2014-11-27)
We sought to develop an IL-33 vaccine and evaluate its efficacy in a mouse model of asthma. The full-length molecules of putative mature IL-33 were inserted into the immunodominant epitope region of hepatitis B core antigen using gene recombination techniques.
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