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H125

Sigma-Aldrich

(2-Hydroxypropyl)-γ-cyclodextrin

solid

Synonyme(s) :

HGC

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About This Item

Numéro CAS:
128446-34-4
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.77

Forme

solid

Concentration

1.000 mg/mL±0.005

Technique(s)

cell culture | mammalian: suitable

Couleur

white

Solubilité

H2O: 450 mg/mL

Conditions d'expédition

ambient

Température de stockage

room temp

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

Clé InChI

ODLHGICHYURWBS-RYJYQAAZSA-N

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Application

(2-Hydroxypropyl)-γ-cyclodextrin has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CCs) from plasma samples.

Actions biochimiques/physiologiques

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation.

Autres remarques

Non-toxic solubilizer. γ-Cyclodextrin (8-glucose units) has a slightly larger cavity and can accommodate larger substrates than β-cyclodextrin.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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α-Cyclodextrin ≥98%

Sigma-Aldrich

C4642

α-Cyclodextrin

(2-Hydroxyethyl)-β-cyclodextrin extent of labeling: ~0.7 mol per mol cellulose

Sigma-Aldrich

389137

(2-Hydroxyethyl)-β-cyclodextrin

Acetyl-β-cyclodextrin Monoacetyl-β-cyclodextrin

Sigma-Aldrich

A3724

Acetyl-β-cyclodextrin

Catherine R Barker et al.
International journal of cancer, 118(11), 2685-2693 (2005-12-31)
The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches
Role of cyclodextrins in improving oral drug delivery
Loftsson T, et al.
The American Journal of Drug and Alcohol Abuse, 261-275 (2004)
Ashutosh Singhal et al.
Scientific reports, 10(1), 8663-8663 (2020-05-28)
Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 and NPC2 genes that result in an accumulation of cholesterol in lysosomes. The majority of children with NPC die in adolescence. Currently, no FDA-approved therapies
Daria Cosaceanu et al.
Cancer letters, 222(2), 173-181 (2005-05-03)
Targeted disruption of the insulin-like growth factor 1 receptor (IGF-1R) restricts proliferation of tumor cells and enhances their in vitro radiosensitivity. However, there is little information regarding the effect of IGF-1R expression and function on the lung cancer response to
Complexation Thermodynamics of Cyclodextrins.
Mikhail V. Rekharsky et al.
Chemical reviews, 98(5), 1875-1918 (2002-02-19)
Afficher tous les articles scientifiques apparentés

Articles

Cyclodextrin Solubility Table

Solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl beta-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.

Cyclodextrins

Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.

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