Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

GE17-5269-02

MabSelect™ Xtra

Cytiva 17-5269-02, pack of 200 mL

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
41106500
Nomenclature NACRES :
NA.56

ligand

recombinant protein A (E. coli)

Conditionnement

pack of 200 mL

Fabricant/nom de marque

Cytiva 17-5269-02

Conditions de stockage

(20% Ehtanol)

Matrice

highly cross-linked agarose

Taille moy. des particules

75 (d₅₀v is the median particle size of the cumulative volume distribution)

cleaning in place

2-12

Plage de travail

3-10

Capacité

≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)

Adéquation

suitable for bioprocess medium

Température de stockage

2-8°C

Catégories apparentées

Description générale

Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
MabSelect™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.

Application

MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion Proteins.

The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.

Caractéristiques et avantages

  • Higher dynamic binding capacity than currently available Protein A chromatography media.
  • Improved process economics through reduced raw materials costs and/or reduced number of cycles
  • High purity capture due to high ligand selectivity and matrix hydrophilicity
  • Slightly lower pressure/fLow properties compared to MabSelect™ SuRe™ and MabSelect

Stockage et stabilité

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.

Remarque sur l'analyse

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Informations légales

MabSelect is a trademark of Cytiva
SuRe is a trademark of Cytiva

Pictogrammes

Flame
GHS02

Mention d'avertissement

Warning

Mentions de danger

H226

Code de la classe de stockage

3 - Flammable liquids

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Articles

Column Packing and Preparation for Affinity Chromatography of Antibodies

This page describes efficient column packing and preparation for affinity chromatography of antibodies.

Contenu apparenté

Sample Purification

Purification methods for downstream analysis reduce sample complexity, remove interferences, and concentrate analytes for more accurate results.

Purification d'échantillons

Diverses méthodes de purification peuvent être utilisées pour préparer un échantillon avant l'analyse. La purification permet de réduire la complexité de l'échantillon, d'éliminer les interférences et de concentrer un analyte avant l'analyse.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique