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G8634

Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥90% (contains < 10% GDP, HPLC), powder

Synonyme(s) :

GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

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About This Item

Formule empirique (notation de Hill):
C10H12Li4N5O13P3S
Numéro CAS:
94825-44-2
Poids moléculaire :
562.98
Numéro Beilstein :
8182249
Numéro CE :
305-606-1
Numéro MDL:
MFCD00135151
Code UNSPSC :
41106305
ID de substance PubChem :
24895344
Nomenclature NACRES :
NA.77

Pureté

≥90% (contains < 10% GDP, HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

Clé InChI

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
  • as a component of lysis buffer
  • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state
  • to couple with G- protein α, to study its effect on kinase activity

Actions biochimiques/physiologiques

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Sanchez BP, et al.
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Rab27a is an essential component of melanosome receptor for myosin Va
Wu X, et al.
Molecular Biology of the Cell, 13(5), 1735-1749 (2002)
Pilar Sánchez-Blázquez et al.
Cellular signalling, 21(9), 1444-1454 (2009-05-19)
There is a certain cross-talk in the nervous system between N-methyl-D-aspartate receptors (NMDARs) and Mu-opioid receptors (MORs). While NMDARs participate in the desensitization of MORs, these in turn modulate NMDAR-mediated glutamate responses. The G protein coupled receptors (GPCRs) activate NMDARs
Trine Ljungstrom et al.
Pflugers Archiv : European journal of physiology, 446(6), 684-694 (2003-06-27)
Activation of KCNQ potassium channels by stimulation of co-expressed dopamine D(2) receptors was studied electrophysiologically in Xenopus laevis oocytes and in mammalian cells. To address the specificity of the interaction between D(2)-like receptors and KCNQ channels, combinations of KCNQ1-5 channels
Jana Omar et al.
Scientific reports, 11(1), 10317-10317 (2021-05-15)
Alongside its biosynthetic functions, the small GTPase Rab12 negatively regulates mast cell (MC) exocytosis by its interaction with RILP to promote retrograde transport of the MC secretory granules. Given the role of Rab effectors in mediating Rab functions, in this
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

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