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G1796

Sigma-Aldrich

Glycolide

≥99%

Synonyme(s) :

1,4-Dioxane-2,5-dione

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About This Item

Formule empirique (notation de Hill):
C4H4O4
Numéro CAS:
502-97-6
Poids moléculaire :
116.07
Numéro CE :
207-954-9
Numéro MDL:
MFCD00081108
Code UNSPSC :
12162002
ID de substance PubChem :
329799848
Nomenclature NACRES :
NA.23

Pureté

≥99%

Pf

82-86 °C (lit.)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

O=C1COC(=O)CO1

InChI

1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2

Clé InChI

RKDVKSZUMVYZHH-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.

Application

Glycolide can be used as a monomer in the preparation of poly(lactic-co-glycolide)(PGLA) via copolymerization with lactide monomer. PGLA is further used in the following applications:
  • Porous PGLA microsphere scaffolds are used in bone repair applications.
  • Encapsulated PGLA nanoparticles can be used in drug delivery and tissue engineering applications. Polymeric micro/nanoparticles made from PLGA have gained significant interest for their appealing characteristics, including biodegradability, biocompatibility, prolonged drug release, and safeguarding the drug against degradation.
It can also be used to synthesize poly(glycolide-caprolactone)(PGCL) copolymers applicable as bioabsorbable suture materials.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Towards electroactive gel artificial muscle structures
Electroactive Polymer Actuators and Devices (EAPAD) XX, 10594, 1059408-1059408 (2018)
Types of biodegradable polymers
Introduction of Bioplastic Engineering, 81-151 (2016)
J L Guo et al.
Science advances, 5(6), eaaw7396-eaaw7396 (2019-06-12)
Synthetic hydrogels are investigated extensively in tissue engineering for their tunable physicochemical properties but are bioinert and lack the tissue-specific cues to produce appropriate biological responses. To introduce tissue-specific biochemical cues to these hydrogels, we have developed a modular hydrogel
Zohreh Arabpour et al.
Journal of biomedical materials research. Part A, 107(10), 2340-2349 (2019-06-05)
Tissue engineering is one of the most promising areas for treatment of various ophthalmic diseases particularly for patients who suffer from limbal stem cell deficiency and this is due to the lack of existence of appropriate matrix for stem cell
Yutong Han et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(15), 1900251-1900251 (2019-08-14)
Due to specific immune recognition receptors on the surface of T cells, their membranes are promising mimic nanocarriers for delivering drugs to tumor lesions. However, this single targeting strategy potentially compromises therapy efficacy for tumor targeting due to inter- and
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