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F7879

Sigma-Aldrich

Ferritin, cationized from horse spleen

10 mg/mL in 0.15 M NaCl

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26

Source biologique

horse spleen

Niveau de qualité

Stérilité

sterile-filtered

Forme

liquid

Concentration

10 mg/mL in 0.15 M NaCl

Technique(s)

cell culture | mammalian: suitable
electron microscopy: suitable

Numéro d'accès UniProt

Température de stockage

2-8°C

Informations sur le gène

horse ... FTL(100051593)

Description générale

Ferritin, an iron-storage protein is usually present in the liver and spleen in mammals. Iron and ferritin are distributed relatively same in the eye. Ferritin is made up of heavy and light chains.

Application

A cationic derivative used to label negatively charged cell membranes for visualization by electron microscopy.
Ferritin is an iron storage protein that plays a central role in iron metabolism, and may be elevated in inflammatory or malignant diseases. It has been used in studies as an indicator of body iron supply, but may prove inaccurate in in the presence of chronic inflammation.
Ferritin, cationized from horse spleen has been used:
  • to incubate amoebae (106) in the study, to determine whether trophozoites are able to take up ferritin and internalise this protein for their growth in axenic culture
  • to determine phagosome-lysosome fusion by electron microscopy
  • to label freshly excised chick optic tecta in serum free incubation medium

Actions biochimiques/physiologiques

Ferritin holds iron at its ferric state (Fe3+). The core of ferritin has the capability to hold 4500 iron molecules. It is essential to store iron in vertebrates. Ferritin is also essential to store and transport iron in invertebrates. It plays a key role in dietary iron absorption.

Notes préparatoires

Prepared by coupling horse spleen ferritin with N,N-dimethyl-1,3-propanediamine (DMPA).

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Recycling of plasmalemma in chick tectal growth cones
Cheng, TP and Reese, TS
The Journal of Neuroscience, 7(6), 1752-1759 (1987)
Fabrizio Bardelli et al.
Scientific reports, 7, 44862-44862 (2017-03-24)
Once penetrated into the lungs of exposed people, asbestos induces an in vivo biomineralisation process that leads to the formation of a ferruginous coating embedding the fibres. The ensemble of the fibre and the coating is referred to as asbestos
Iron-Induced Retinal Damage
Handbook of nutrition, diet, and the eye, 619-626 (2014)
Ferritin
Reference Module in Life Sciences (2017)
Use of cationized ferritin as a label of negative charges on cell surfaces.
D Danon et al.
Journal of ultrastructure research, 38(5), 500-510 (1972-03-01)

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