E4018

(−)-Épicatéchine

≥98% (HPLC), from green tea

• Synonyme(s) : (−)-cis-3,3′,4′,5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphényl)-3,4-dihydro-1(2H)-benzopyrane-3,5,7-triol
• Formule empirique (notation de Hill): C₁₅H₁₄O₆
• Numéro CAS: 490-46-0
• Poids moléculaire : 290.27
• Numéro Beilstein : 92760
• Numéro CE : 207-710-1
• Numéro MDL: MFCD00075648
• Code UNSPSC : 12352205
• ID de substance PubChem : 24894538
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: green tea
• Niveau de qualité: 200
• Pureté: ≥98% (HPLC)
• Pf: 240 °C (dec.) (lit.)
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: 2-8°C
• Chaîne SMILES: O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3
• InChI: 1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
• Clé InChI: PFTAWBLQPZVEMU-UKRRQHHQSA-N
• Informations sur le gène: human ... BACE1(23621) , CYP1A2(1544)

Description

Description générale

Epicatechin is a flavanol, that belongs to the class of secondary, polyphenolic plant metabolites.

Application

(-)-Epicatechin has been used:

• to examine its biological effects in cell lines from human gender-specific cancers
• to study its antiviral activity
• to test its ability to regenerate this enzymatic activity both in vitro at the isolated MPO−H₂O₂−Cl- system and ex vivo in human polymorphonuclear leukocytes (PMNs)

Actions biochimiques/physiologiques

This antioxidant is found in chocolate. (-)-Epicatechin is linked with cardiovascular effects. It is considered as a dependable standard due to its availability in cacao seeds and cocoa products. The halogenating activity of myeloperoxidase can be restored by (-)-epicatechin.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves