D6694

Anti-DSCR1 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : Anti-ADAP78, Anti-Calcipressin 1, Anti-DSC1, Anti-Down Syndrome Candidate Region 1, Anti-MCIP1, Anti-Myocyte-enriched calcineurin-interacting protein 1, Anti-RCAN1, Anti-RCN1, Anti-Regulator of calcineurin 1
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.44

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~26 kDa
• Espèces réactives: mouse, rat, human
• Concentration: ~1.5 mg/mL
• Technique(s): western blot: 2-4 μg/mL using HEK-293T cells expressing human DSCR1
• Numéro d'accès UniProt: P53805
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... RCAN1(1827) ; mouse ... Dscr1(54720) ; rat ... Dscr1(266766)

Description

Description générale

DSCR1 (Down Syndrome Candidate Region 1 is encoded by a gene mapped to human chromosome 21q22.1. DSCR1 belongs to a family of conserved proteins named regulators of calcineurin (RCAN), that in humans include RCAN, encoded by the DSCR1L1-2 genes. DSCR1 is highly expressed in the central nervous system (CNS) during early embryonic development, in heart, and in skeletal muscle.

Spécificité

Anti-DSCR1 (C-terminal) antibody is specific for DSCR1 in rats, mice and humans. The immunizing peptide specifically inhibits the staining of DSCR1 by immunoblotting.

Immunogène

Synthetic peptide corresponding to a sequence at C-terminal of human DSCR1, conjugated to KLH. This sequence is identical in human DSCR1 isoforms a and b, and rat and mouse DSCR1.

Application

Anti-DSCR1 (C-terminal) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human DSCR1) and in immunoblotting (approx. 26 kDa).

Anti-DSCR1 (C-terminal) antibody produced in rabbit has been used in proximity ligation assay (PLA) and immunoblotting.

Actions biochimiques/physiologiques

Down Syndrome Candidate Region 1 (DSCR1) is involved in cellular adaptation to oxidative stress, and interacts with calcineurin to inhibit its phosphatase activity, thereby regulating the calcineurin- Nuclear factor of activated T-cells (NFAT) signaling pathway and affecting central nervous system (CNS) development and angiogenesis. Chronic overexpression of DSCR1 has been implicated in additional pathological conditions including Alzheimer′s disease and cardiac hypertrophy, possibly through inhibition of calcineurin activity. DSCR1 is induced by vascular endothelial growth factor (VEGF) in activated endothelial cells and regulates the expression of inflammatory marker genes such as interleukin-8 (IL-8), tissue factor, E-selectin and cyclooxygenase (Cox-2).

Down Syndrome Candidate Region 1 or DSCR1 is a candidate gene involved in the pathogenesis of Down′s Syndrome (DS). DSCR1 is usually expressed in cardiac, skeletal and brain tissues, whereas its overexpression in fetal brain tissues is associated with DS. DSCR1 inhibits calcineurin-mediated mRNA synthesis.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)