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Principaux documents

D4876

Sigma-Aldrich

Dextrane from Leuconostoc mesenteroides

average mol wt 150,000

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About This Item

Formule linéaire :
(C6H10O5)n
Numéro CAS:
9004-54-0
Numéro CE :
232-677-5
Numéro MDL:
MFCD00130935
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25

Source biologique

bacterial (Leuconostoc mesenteroides)

Niveau de qualité

200

Forme

powder

Activité optique

[α]/D 199°

Poids mol.

average mol wt 150,000

Couleur

white

Solubilité

H2O: soluble 20 mg/mL

Chaîne SMILES 

O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

Clé InChI

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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Application

L'utilisation de dextrans comme longs bras hydrophiles améliore les performances des protéines immobilisées qui agissent sur les macromolécules.
Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextran 150 may be used to study iron delivery to cells, cell membrane permeabilization and red blood cell aggregation.

Notes préparatoires

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Autres remarques

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLCD4173
SLBP2120V
SLBR0333V
120M0048V
120M0048

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Consulter la Bibliothèque de documents

Mengyun Lia et al.
Archives of animal nutrition, 65(6), 477-485 (2012-01-20)
Iron (Fe) is an essential and important trace element for animals. In order to study its metabolism and relationship with hepcidin, piglet models of Fe-deficiency and Fe-overload were established by intramuscular injection with different doses of Fe-dextran (150 mg Fe/ml)
Zhiyang Li et al.
Journal of biomedical nanotechnology, 9(11), 1945-1949 (2013-09-26)
For reducing the steric hindrance and nonspecific binding of the target DNA, the dextran was used as molecular arms to be immobilized on the surface of magnetic nanoparticles (MNPs). Magnetic separation was used in preparation of dextran-MNPs (DMNPs). Aspartic acid
Yang Yang et al.
Biochimica et biophysica acta, 1840(1), 288-293 (2013-10-01)
Abnormal adhesion of red blood cells (RBCs) to vascular endothelium is often associated with reduced levels of sialic acids on RBC membranes and with elevated levels of pro-adhesive plasma proteins. However, the synergistic effects of these two factors on the
Elizabeth M Bradshaw et al.
Nature neuroscience, 16(7), 848-850 (2013-05-28)
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young
Hideto Katsuta et al.
Investigative ophthalmology & visual science, 54(6), 4102-4108 (2013-05-23)
To elucidate the role of signals mediated by EphB4 receptor tyrosine kinase and its transmembrane ephrinB2 ligand in corneal lymphatic capillaries. To detect expression of ephrinB2 and EphB4 in mouse corneas, immunohistochemistry of flat-mount corneas from 6- to 10-week-old wild-type
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Protocoles

Dextran

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-6) linkages. The remaining a(1-3) linkages account for the branching of dextran. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. However, other methods indicate branches of greater than 50 glucose units exist.

Contenu apparenté

Dextran and Related Polysaccharides

Learn about C6H10O6 or dextran formation, classes and naming. Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, which have a linear backbone of α-linked d-glucopyranosyl repeating units.

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