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C8977

Sigma-Aldrich

Monoclonal Anti-CREB antibody produced in rabbit

clone 48H2, purified immunoglobulin, buffered aqueous glycerol solution

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About This Item

Numéro MDL:
MFCD01092316
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

48H2, monoclonal

Forme

buffered aqueous glycerol solution

Poids mol.

antigen 43 kDa

Espèces réactives

rat, human, monkey, mouse

Technique(s)

ChIP: 1:50
flow cytometry: 1:400
immunocytochemistry: 1:800
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:6,400
immunohistochemistry (frozen sections): 1:6,400
immunoprecipitation (IP): 1:250
indirect immunofluorescence: 1:800
western blot: 1:1,000 using extracts from SK-N-MC cells treated with forskolin or FGF

Isotype

IgG

Numéro d'accès UniProt

P16220

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CREB1(1385)
mouse ... Creb1(12912)
rat ... Creb1(81646)

Spécificité

Detects endogenous levels of total CREB protein.

Immunogène

Recombinant protein specific to amino terminus of human CREB.

Forme physique

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and < 0.02% sodium azide with 50% glycerol.

Informations légales

Rabbit monoclonals produced using Epitomics® Technology, U.S.Patent No. 5,675,063.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Min Gyu Lee et al.
The Journal of biological chemistry, 278(42), 41047-41058 (2003-08-02)
A common signature of many cancers is a high glucose catabolic rate frequently dependent on the overexpression of Type II hexokinase (HKII), a mitochondrial bound enzyme that also suppresses cell death. As the tumor HKII promoter plays a significant role
CREB: a mediator of long-term memory from mollusks to mammals.
D A Frank et al.
Cell, 79(1), 5-8 (1994-10-07)
J C Yin et al.
Cell, 81(1), 107-115 (1995-04-07)
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB).
G A Gonzalez et al.
Cell, 59(4), 675-680 (1989-11-17)
In this paper, we demonstrate that phosphorylation of CREB at Ser-133 is induced 6-fold in vivo, following treatment of PC12 cells with forskolin. By contrast, no such induction was observed in the kinase A-deficient PC12 line A126-1B2 (A126). Using F9
R P Kwok et al.
Nature, 370(6486), 223-226 (1994-07-21)
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). CREB is activated through phosphorylation by protein kinase A (PKA), but precisely how phosphorylation stimulates CREB function is unknown. One model is that phosphorylation may
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