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Merck
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Key Documents

Autres documents

C6143

Sigma-Aldrich

Chlorhexidine diacetate salt hydrate

bis(biguanide) antimicrobial

Synonyme(s) :

1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

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About This Item

Formule empirique (notation de Hill):
C22H30Cl2N10 · 2C2H4O2 · xH2O
Numéro CAS:
206986-79-0
Poids moléculaire :
625.55 (anhydrous basis)
Numéro CE :
200-302-4
Numéro MDL:
MFCD00012532
Code UNSPSC :
51101500
ID de substance PubChem :
24892838
Nomenclature NACRES :
NA.85

Niveau de qualité

200

Forme

powder

CMC

0.01% (25°C)(w/v)

Solubilité

ethanol: 50 mg/mL

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Mode d’action

cell membrane | interferes

Température de stockage

room temp

Chaîne SMILES 

ClC1=CC=C(NC(NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N)=N)C=C1.OC(C)=O.OC(C)=O

InChI

1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)

Clé InChI

WDRFFJWBUDTUCA-UHFFFAOYSA-N

Catégories apparentées

Application

Used to study mechanism of membrane dysruption by bis(biguanide) molecules.

Actions biochimiques/physiologiques

Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective against both Gram-positive and Gram-negative bacteria. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Clause de non-responsabilité

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Pictogrammes

Exclamation markHealth hazardEnvironment
GHS07,GHS08,GHS09

Mention d'avertissement

Warning

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

C Harrison et al.
International journal of STD & AIDS, 9(2), 92-97 (1998-03-20)
The effect of chlorhexidine and nonoxynol-9, either singly or in combination, on the replication and infectivity of HIV and the survival of both lymphocytes (MT2 cells) and human spermatozoa, was studied in vitro. Exposure of MT2 cells to 200 microg/ml
E Zaura-Arite et al.
Journal of dental research, 80(5), 1436-1440 (2001-07-05)
Culturing of dispersed plaque samples and vitality staining of plaque smears are the most commonly used methods for evaluating the effects of antimicrobials on dental plaque. The visualization of the antimicrobial action on oral biofilm present on the substrate surface
Angela R Schug et al.
Veterinary microbiology, 248, 108791-108791 (2020-08-23)
Biocide susceptibility testing (BST) of bacteria lacks standardised methods. Based on a recently established broth macrodilution BST method, a broth microdilution method for BST was developed. To establish the respective protocol, four reference strains Staphylococcus aureus ATCC® 6538, Enterococcus hirae
T J Karpanen et al.
The Journal of antimicrobial chemotherapy, 62(5), 1031-1036 (2008-08-16)
Effective skin antisepsis and disinfection of medical devices are key factors in preventing many healthcare-acquired infections associated with skin microorganisms, particularly Staphylococcus epidermidis. The aim of this study was to investigate the antimicrobial efficacy of chlorhexidine digluconate (CHG), a widely
Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides.
Liu WS, Wang CH, Sun JF, et al.
Chemical Biology & Drug Design, 85(1), 91-97 (2014)
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